Specialty:

Neurophysiologist | Molecular Biologist | Geneticist

See detailed CV

Dr. El. Georgakopoulos

Dr. Georgakopoulos is one of the world’s leading scientists in the field of genetics and molecular biology, with a huge scientific and research work and numerous awards.

He was specialized in genetics by the eminent University of Heidelberg Professor K.-H. Matzura and in Neurophysiology by the distinguished Professor of the School of Medicine of the same University, M. Zimmerman.

He is a Member of the New York Academy of Sciences, while he has collaborated in research and science with Nobel laureates in the fields of medicine and biology. He collaborated for 3 years with Carlos Cordon Cardo, who was nominated for the Nobel Prize for the discovery of the breast cancer gene, HER2.

Dr. Georgakopoulos has been active, among others, in the fields of biotechnology, molecular diagnostics, nanobiotechnology and molecular applications. He holds 17 national and international patents and has been awarded with numerous national and international awards.
During his scientific career, he founded and organized the Molecular Biology and Genetics Unit at the Athens Medical Center, where he developed special activity with the execution of 5 research programs, in epithelial type cancer and the possibility of early diagnosis of micrometastatic disease in cancers of epithelial organs.
He directed Acrogenomics Inc, listed on the New York Stock Exchange, one of the largest companies in the world in genetics and nanotechnology. The company’s research program aimed at developing nanoparticles and identifying their properties for use in clinical applications.

In 2008 he took over the management of the stem cell quality system of the Hygeia group.

1. Georgakopoulos E., McMenamin M. and Skouteris GG (1995): “Phospholipase A2 is activated by tumor necrosis factor -α in primary hepatocytes stimulated by a deleted form of hepatocyte growth factor”. Biochemical and Biophysical Research Communication, 217, 1263-1270.

2. Skouteris GG and Georgakopoulos E. (1996): “Hepatocyte growth factor induced proliferation of primary hepatocytes is mediated by activation of phosphatidylinositol 3-kinase”. Biochemical and Biophysical Research Communication, 218, 229-233.

3. Blume A., Georgakopoulos E., Lebrun C., Culman J., Möllenhoff E., Herdegen T. and Unger T. (1996): “Arginine-vasopressin as target of angiotensin II in the brain in vitro”. Regulatory Peptides, Volume 64, 1-3, 14.

4. Herdegen T., Blume A., Buschman T., Georgakopoulos E., Winier C., Schmid W., Hsiem F., Zimmerman M and Gass P. (1997): “Expression of activating transcription factor-2, serum response factor and cAMP/Ca response element binding protein in the adult rat brain following generalized seizures, nerve fiber lesion and ultraviolet irradiation”. Neuroscience, 81, 190-212.

5. Karanikiotes C., Skiadas I., Karina M., Georgakopoulou S., Georgakopoulos E. and Fountzilas G (2005): “Novel chromatographic molecular method for the detection of the membrane cancer antigen Ep-CAM (17-1A) in peripheral blood and bone marrow of patients with metastatic colorectal cancer”, Anticancer Research, Jan-Feb; 25(1A): 319-23.

6. Papadopoulou E., DavilasE., Sotiriou V., Georgakopoulos E., Georgakopoulou S., Koliopanos K, Aggelakis F., Dardoufas K., Agnanti JN., Karydas I, Nasioulas G. (2006): “Cell-free DNA and RNA in Plasma as a New Molecular Marker for Prostate and Breast Cancer”, Annals of the New York Academy of Sciences, 1075, 2423-2435.

Distinctions

In recognition of his significant clinical and research work, Dr. Eleftherios Georgakopoulos has received numerous national and international honors and awards.

The most important of these are:

2000   9th Hellenic Congress of Clinical Oncology, April 2000.

2000   European Association of Medical Oncology, 25th ESMO Congress, 2000 

2001  10th Hellenic Congress of Clinical Oncology, April 2001.

2002  Award from the Minister of Development and the Organization of  Industrial Property for my invention with number 1003455 and title: “New  method of detection of 17-1A in peripheral blood and in tissues and  determination of micrometastatic cancer cells in patients with various  types of cancer ».

2002   HPV and EBV infection and their relation to apoptosis and angiogenesis  related proteins in operable laryngeal carcinomas, ESMO, October 2002.

2002   For significant Accomplishments and Achievements, Greek Republic.

2003   The infection with EBV and HPV and their relation with the expression of bcl- 2, wt-p53, vEGF and HER1 in patients with operable laryngeal cancer, 12th  North Greek Medical Congress, Mai 2003.

2003  Marquis Who’s WHO Organization, Who is Who In the World, 21rst Edition,  2004

2004   2000 Outstanding Intellectuals of the 21st Century, International  Biographical Centre, Cambridge, England.

2004   Man of the Year, International Biographical Centre, Cambridge, England.

2004   Great Minds of the 21st Century, American Biographical Institute, USA

2004   International Peace Prize, United Nations Cultural Convention, USA

2004  Marquis Who’s WHO Organization, Who is Who In the World, 22rst Edition,  2005

2004   21st Century Award for Achievement, Illuminated Diploma Of Honour,  International Biographical Centre, Cambridge, England.

2005  Marquis Who’s WHO Organization, Who is Who In the World, 23rd Edition

2005  American Medal of Honor, American Biographical Institute, USA

2005   Man of the Year, Registered in the Institute Library and Archives in the United States of America, American Biographical Institute, USA 

2011:  Who is Who in Greece

Patents

The rich research work of Dr. Eleftheriou Georgakopoulos is confirmed by the 17 national and international patents he holds. In detail:

1.  Patent with Number 1003455 and title:
“New method of detection of 17-1A in peripheral blood and tissues and determination of metastatic cancer cells in patients with various types of cancer”. 

2.  Patent to the Industrial Property Organization with Number 1004303 entitled:
“New method of detection of 17-1A in peripheral blood and tissues and determination of metastatic cancer cells in patients with various types of cancer”. 

3.  Patent with Number 1003896 and title:
“New method for detection and identification of point mutations of hepatitis B virus (HBV) strains in patient blood serum”. 

4.  Patent with Number 1003878 and title:
“New method of isolation of total ribonucleic acids (total RNA) from paraffin tissues”. 

5.  Patent at the Industrial Property Organization with Application Number 990100391 entitled:
“New method for the detection of cancer membrane antigen Ep-Cam and determination of circulating micrometastatic cancer cells in the peripheral blood (and tissues) of patients with cancer of epithelial origin”. 

6.  Patent granted by NCBI for the Ep-CAM membrane cancer antigen sequence. 

7.  Patent granted by the EPO for the molecular detection of membrane cancer antigen Ep-CAM. 

8.  Patent modification with Number 1004765 on Patent with Number 1004303 titled:
“Detection of cancer membrane antigen Ep-Cam and determination of circulating micro-metastatic cancer cells in peripheral blood of patients (and in tissues) with cancer of epithelial origin”. 

9.  Patent with Number 1004959, titled:
“Prototype RT and PCR protocols with the use of Neowater for the detection epithelial cell adhesion molecule EpCAM and detection of circulating micro-metastatic cancer cells in peripheral blood (and tissue) of patients with cancer of epithelial origin’. 

10.  “Prototype RT and PCR protocols with reduced quantities of reagents without MgCl2 and with the use of Neowater for the detection epithelial cell adhesion molecule EpCAM and detection of circulating micro-metastatic cancer cells in peripheral blood (and tissue) of patients with cancer of epithelial origin’. 

11.  Patent with Number 1004964, titled:
“Prototype RT and PCR protocols, with minimal concentration of reagents, without magnesium chloride using Neowater and detection of cancer membrane antigen Ep-Cam and identification of circulating micrometastatic cancer cells in peripheral blood (and tissues) in patients with cancer of epithelial origin’. 

12.  Patent with Number 1004965, titled:
“Prototype RT and PCR protocols using Neowater without use of the reverse primer and magnesium chloride and detection of cancer membrane antigen Ep-Cam and identification of circulating micrometastatic cancer cells in peripheral blood (and tissues) in patients with cancer of epithelial origin’. 

13.  European Patent with Number EP1612278, titled:
“Method for the detection and identification of epithelial micro-metastatic cancer cells”. 

14.  Patent with Application Number 20060014174 Submitted to US Patent Office, titled:  “Method for the detection and identification of epithelial micro-metastatic cancer cells”. 

15.  Patent with Number CA 2502756 (Canadian Patent Office), titled:
“Method for the detection and identification of epithelial micro-metastatic cancer cells”. 

16.  Patent with Number 20050100370 Submitted to Greek Industrial Organization Office (pending), titled:
“Detection and quantification of nucleic acids (DNA/RNA) in peripheral blood, tissues and body fluids”. 

17.  Patent with Number 20050100 Submitted to Greek Industrial Organization Office (pending), titled:
“Detection and quantification of nucleic acids (DNA/RNA) in peripheral blood, tissues and body fluids”.

Patents

Dr. E. Georgakopoulos had and has an active participation in the most important conferences held worldwide in the field of Genetics. Specifically:

  • European Society of Neuroscience, 1994
  • Society for Neuroscience, 1995
  • 23rd Göttingen Neurobiology Conference
  • MR Screening in Women at High Genetic Risk of Breast Cancer. Current and Planned Studies, International Collaboration and Combined Analysis
  • 22nd International Breast Cancer Research Congress of the IABCR
  • 9th Panhellenic Congress of Clinical Oncology, April 2000*
  • His work was awarded first prize
  • European School of Oncology, Athens 1999
  • European School of Oncology, Kos 2000
  • HeCOG meetings every four months during 2000*
  • European Association of Cancer Research, XVI EACR Congress, 2000
  • European School of Oncology, Thessaloniki 2000
  • HeCOG Meeting, October 2000*
  • European Association of Medical Oncology, 25th ESMO Congress, 2000
  • Association of Biomedical Technology of Crete, November, 2000*
  • 10th Panhellenic Congress of Clinical Oncology, April 2001*
  • Guest lecture series of the German Federal Minister of Health, Duesseldorf, June 2001*
  • Biotechnology Meeting, Mykonos, July 2001*
  • HeCOG meetings every four months during 2001*
  • Association of Biomedical Technology of Crete, November, 2001*
  • HPV and EBV infection and their relation to apoptosis and angiogenesis related proteins in operable laryngeal carcinomas, ESMO, October 2002
  • Detection of HER 1, HER 2, HER 3 and HER 4 in patients receiving Taxol+Carboplatin+Iressa with advanced breast cancer, HECOG, June 2002
  • EBV and HPV infection and their relationship to proteins involved in apoptosis and angiogenesis in surgically resectable laryngeal cancer, HECOG, June 2002*
  • The prognostic role of proteins involved in apoptosis and angiogenesis in patients with high-risk operable rectal and colon cancer after FU/LEUCOVORIN chemotherapy according to HECOG protocols: He 6c/91, He 6d/91, He 6d/98, He 6d/99, He 6c/98, He 6c/99,He 6e/99, HECOG, June 2002
  • The prognostic role of TP and TS proteins in patients with high-risk operable rectal and colon cancer after chemotherapy with FU/LEUCOVORIN according to HECOG protocols: He 6c/91, He 6d/91, He 6d/98 , He 6d/99, He 6c/98, He 6c/99, He 6e/99, HECOG, June 2002.
  • From concept to OBI and PCT process, Crete May 2002*
  • Targeting HER-2 and EGFR, EOPE, August 2002*
  • The contribution of molecular techniques in determining prognosis, EOPE, September 2002*
  • Detection of Ep-Cam antigen in patients with metastatic breast cancer, HECOG, October 2002*
  • The contribution of translational research to the establishment of new prognostic and predictive factors in breast cancer, HECOG, October 2002*
  • EBV and HPV infection and their relationship with proteins involved in apoptosis and angiogenesis in surgically resectable laryngeal cancer, 10th Postgraduate Clinical Oncology Seminar, Crete, November 2002*
  • Detection of CK-19 mRNA and Ep-Cam antigen and micrometastatic tumor cells in patients with operable node-positive breast cancer receiving chemotherapy ET-CMF vs ET-CMF, 10th Postgraduate Clinical Oncology Seminar, Crete, November 2002*
  • Molecular diagnostics and cancer. New approach to residual disease detection. A new PCR product detection system, Panhellenic Clinical Chemistry Conference, Athens November 2002*
  • Case Report: Treatment of Astrocytoma in combination with XMT and with the application of Functional Medicine, World Congress of Functional Medicine, San Francisco, USA, November 2010*

*Guest speaker