1. What is Precision Medicine?

Precision Medicine aims at prevention, diagnosis and treatment strategies that take into account individual variability that incorporates genes, environment and lifestyle with an emphasis on personalized genetic profiling for diagnosis and risk assessment. Research results continue to clearly confirm that the prevention of non-communicable diseases requires interventions that simultaneously target multiple risk factors.

2. How is individual variability in genes, environment and lifestyle controlled in Precision Medicine?

In Precision Medicine, various methods are used to ascertain individual variability: The individualized genetic profile is analyzed by elucidating – detecting and qualifying the SNPs of the target genes. These polymorphisms differentiate the response of each person and confirm that the genetic profile leads us to diagnosis and risk assessment and makes us unique. The effect of environment and lifestyle is analyzed by metabolomic analysis, which includes urine metabolomics, plasma lipidomics and aminomics. Thus the metabolomics performed corresponds to a comprehensive analysis of metabolites, i.e. small molecules (< 1 kDa) of an organism or a specific biological sample. Metabolomics, delineates the metabolites within a cell or biological system and offers a unique opportunity to study the effect of genetic variation, disease, applied therapy or nutrition on the endogenous metabolic state of organisms, oxidative stress and aging .

3. How can we intervene with Precision Medicine

Having all the necessary information from the tests can be given and implemented personalized instructions for changing the lifestyle and diet as well as planning annual checks in relation to individual variability such as in the case of mutations in the insulin receptor, where the control of hyper -insulinemia becomes imperative. The results of the tests lead to personalized administration of nutritional supplements, e.g. to combat oxidative stress, but also in combination with pharmaceutical preparations to prevent either micro-inflammation or hyperlipidemia as in cases of increased cardiovascular risk in combination with mutations and a disturbed metabolomic and lipid profile.