Psoriasis
Personalized tests to detect metabolites (small molecules) and gene variants associated with Psoriasis
Psoriasis is an autoimmune inflammatory, chronic skin disease that significantly affects the patient’s quality of life and occurs in several types such as plaque psoriasis, nail psoriasis, enteric psoriasis, inverse psoriasis, pustular psoriasis, erythrodermic psoriasis and psoriatic arthritis
The Invisible Enemies of Health: What are the factors associated with psoriasis?
Psoriasis is a multifactorial disease caused by the interaction between factors such as:
- Genes: Genetic variants and single nucleotide polymorphisms (SNPs) identified through genomic studies play an important role in the predisposition to psoriasis. For more information, visit our epigenome page .
- The increased production of oxidative oxygen radicals (ROS) and the dysfunction of antioxidant systems: The total antioxidant capacity and the level of protection against oxidation is significantly reduced in patients with psoriasis compared to healthy people, while the total oxidative load is particularly increased. Also the total antioxidant capacity and the level of protection against oxidation is related to the severity of the disease.
- Unhealthy Lifestyle: Stress is one of the most common factors that trigger psoriasis. Bad eating habits, and the Western-style diet, characterized by its high sugar and fat content, can lead to significant skin inflammation and psoriasis flare-ups. It also affects the composition of the gut microbiome.
- The intestinal microbial flora: Study of the gut microbiome and enterotype demonstrated a specific pattern in psoriatic patients, clearly different from that found in the healthy population.
- Environment and Xenobiotics (chemicals): Cold weather can often trigger psoriasis flare-ups due to less sunlight and humidity, warmer and drier indoor air. Xenobiotics contribute to the pathogenesis of psoriasis. The mechanism linking xenobiotic stimuli to epidermal proliferation is constantly being investigated.
- Energy Intake and Metabolism: Many epidemiological studies of varying designs link psoriasis to other diseases such as obesity, hyperlipidemia, cardiovascular disease, and diabetes. The metabolism of lipids and their peroxidation from the oxidative load is another main feature, since polyunsaturated fatty acids (PUFA’s) are the important targets of free radicals.
The FGA Center approach
With the latest science and specialized tests, we evaluate the genetic, physiological and environmental factors that contribute to psoriasis. We analyze single nucleotide polymorphisms (SNPs) and associated genetic variants to provide you with a personalized approach.
Our approach includes:
- Personalized Metabolite Analysis: We identify metabolites related to energy intake and metabolism, the antioxidant mechanism and its functions, the microbial flora, the influence of diet, environmental factors, xenobiotics and stress.
- Personalized Nutrition Programs: According to your specialized results, we propose specialized and individual nutrition programs that respond to the best treatment of psoriasis.
- Nutritional Supplements and Lifestyle: We provide advice on specific supplements and lifestyle changes to help you achieve your goals.
- Ongoing Support: We monitor biological needs as they arise to ensure your long-term success.
Discover the possibilities that science gives us with the help of the FGA Center.
